Methyl Salicylate Cream
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MENTHOL; METHYL SALICYLATE (MEN thol; METH il sa LIS i late) relieves minor pain in your muscles and joints. It works by making your skin feel warm or cool, which blocks pain signals going to the brain. It also decreases inflammation. This product contains a salicylate.
Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. Heat the polyethylene glycol (PEG) 4,000 to about 75C. Add the mephenesin powder and stir until dissolved. Add the capsicum oleoresin and stir until dissolved. Add the PEG 400, mix well, and cool to about 60C. In a separate vessel, mix the methyl salicylate, menthol, camphor, and methyl nicotinate and stir until dissolved. Add this solution to the PEG mixture and mix well. Cool to room temperature while mixing. Package and label.
Methyl salicylate (C8H8O3, MW 152.15) occurs as a colorless, yellowish, or reddish liquid with the characteristic odor and taste of wintergreen. It is slightly soluble in water and is soluble in alcohol and glacial acetic acid. Methyl salicylate should be preserved in tight containers; certain plastic containers (polystyrene) are unsuitable for liniments or ointments containing methyl salicylate. Methyl salicylate is absorbed through the skin and is applied topically in rheumatic conditions.2,3
Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. It is used in many over-the-counter products, including muscle ache creams. It is related to aspirin. Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. This can be by accident or on purpose.
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments. It forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. It is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic in mouthwash solutions.
Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago,sciatica and rheumatic conditions. Local analgesics for human and veterinary medicine.
Methyl salicylate relieve musculoskeletal pain in the muscles, joints, and tendons by causing irritation and reddening of the skin due to dilated capillaries and increased blood flow. It is pharmacologically similar to aspirin and other NSAIDs but as a topical agent it primarily acts as a rubefacient and skin irritant. Counter-irritation is believed to cause a soothing sensation of warmth.
Counter-irritation is thought to be effective at alleviating musculoskeletal pain as the irritation of the sensory nerve endings is thought to alter or offset pain in the underlying muscle or joints that are served by the same nerves 5. This is thought to mask the underlying musculoskeletal pain and discomfort. When applied topically, methyl salicylate is thought to penetrate the skin and underlying tissues where it reversibly inhibits cyclooxygenase enzyme and locally and peripherally prevents the production of inflammatory mediators such as prostaglandin and thromboxane A2.
After absorption, methyl salicylate is distributed throughout most body tissues and most transcellular fluids, primarily by pH dependent passive processes. Salicylate is actively transported by a low-capacity, saturable system out of the CSF across the choroid plexus. The drug readily crosses the placental barrier.
Minor metabolism may occur in various tissues but hepatic metabolism constitutes the majority of metabolic processes of absorbed methyl salicylate. It is mainly hydrolyzed to salicylic acid via hepatic esterase enzymes. Conjugation with glycine forms salicyluric acid and conjugation with glucuronic forms ester or acyl and ether or phenolic glucuronide, which are the three main metabolites.
The plasma half-life for salicylate is 2 to 3 hr in low doses and about 12 hr at usual anti-inflammatory doses. The half-life of salicylate may be as long as 15 to 30 hr at high therapeutic doses or when there is intoxication.
Oral LD50 values (mg/kg) for mouse, rat and rabbit are 1110, 887 and 1300, respectively. Oral LD50 values for child and adult human (mg/kg) are 228 and 506, respectively. Although systemic toxicity from topical administration is rare, methyl salicylate can be absorbed in intract skin to cause stimulation of the central nervous system respiratory center, disturbance of lipid and carbohydrate metabolism, and disturbance of intracellular respiration. Severe toxicity can result in acute lung injury, lethargy, coma, seizures, cerebral edema, and death. In case of salicylate poisoning, the treatment consists of general supportive care, gastrointestinal decontamination with activated charcoal in cases of salicylate ingestion, and monitoring of serum salicylate concentrations. Bicarbonate infusions or hemodialysis can be used to achieve enhanced salicylate elimination 7.
Menthol/methylsalicylate topical products should be used with caution with blood thinning medications like warfarin (Coumadin), nonsteroidal anti-Inflammatory drugs (NSAIDs), and steroids due to increased likelihood of bruising and bleeding resulting from methylsalicylate which acts like aspirin and can affect blood clotting.
Menthol/methylsalicylate creams and patch are stored between 20 C to 25 C (68 F to 77 F). Balms are stored between 15 C to 30 C (59F to 86 F). Sprays, sticks, and foams should be stored away from heat and direct sunlight.
Menthol and methylsalicylate (Bengay, Icy Hot, Mentholatum D, Salonpas) is a medication used to treatment of minor aches and joint pain due to arthritis, sprains, strains, bruises, and backaches. Side effects, drug interactions, warnings and precautions, and dosage information should be reviewed prior to taking this medication.
Neck pain (cervical pain, cervicalgia) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Warning symptoms of methyl salicylate toxicity range from fatigue, nausea, hallucinations, dizziness, difficulty breathing, convulsions, ringing in the ears and vomiting. How well one recovers from methyl salicylate poisoning is dependent upon how quickly the treatment is received and on the amount of salicylate present in the blood.
Although synthetic methyl salicylate is prominently known for its role as an analgesic in sports creams, the compound also occurs naturally in oil of wintergreen. The plant likely produces it to ward off predators. Historically methyl salicylate was isolated from the plant by distillation but now it is produced commercially through the esterification of salicylic acid with methanol.
Oil of wintergreen is a popular flavouring agent used in food, chewing gum and candies. Not to worry! 0.04% is the highest amount of methyl salicylate used in candy flavouring. In addition to being a flavour agent, wintergreen oil is a trendy fragrance, perfume and body oil. Exposure through these products is very different from applying excessive amounts to the skin. Remember to use creams containing methyl salicylate only according to directions on the label.
[9-13-2012] The U.S. Food and Drug Administration (FDA) is alerting the public that certain over-the-counter (OTC) products that are applied to the skin for the relief of mild muscle and joint pain have been reported to cause rare cases of serious skin injuries, ranging from first- to third-degree chemical burns, where the products were applied. These OTC topical muscle and joint pain relievers are available as single- or combination-ingredient products that contain menthol, methyl salicylate, or capsaicin. The various formulations include creams, lotions, ointments, and patches.
When applied to the skin, the products produce a local sensation of warmth or coolness; they should not cause pain or skin damage. However, there have been rare cases of serious burns following their use (see Data Summary below). Some of the burns had serious complications requiring hospitalization. In many cases, the burns occurred after only one application of the OTC topical muscle and joint pain reliever, with severe burning or blistering occurring within 24 hours of the first application. Based on the reported cases, the majority of second- and third-degree burns occurred with the use of products containing menthol as the single active ingredient, and products containing both menthol and methyl salicylate, in concentrations greater than 3% menthol and 10% methyl salicylate. Few cases reported using a capsaicin-containing product.
Methyl salicylate is a nonsteroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). This medicine works by reducing substances in the body that cause pain and inflammation.
Camphor, lidocaine, and methyl salicylate topical (for the skin) is a combination medicine used to provide temporary relief of mild to moderate aches and pains of the muscles and joints. This medicine may be used for pain caused by muscle stiffness or bruising, arthritis, sprains or strains, backaches, and sore or bruised muscles.
This medicine contains methyl salicylate, which is an NSAID. An NSAID can increase your risk of fatal heart attack or stroke, especially if you use it long term, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while using an NSAID. 59ce067264
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